Sickle Cell Anemia Teacher Resources

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Students identify the different steps involved in DNA transcription. In this genetics lesson, students model the translation process. They watch a video on sickle cell anemia and explain how different alleles create this condition.
High schoolers examine different levels of organization in biological systems for structure and function relationships.  In this biological systems lesson, students use Internet resources to look at structure and function in the eye, the cell, protein synthesis, and sickle cell anemia.  Resources and detailed instructions are provided. 
Students are presented with a scenario that requires them to electrophoreses human hemoglobin samples in order to confirm a diagnosis of sickle cell anemia and/or to determine whether individuals in the scenario are carriers of the sickle cell allele. They are asked to analyze the separation of the different types of hemoglobin on the gel.
Students investigate how selective forces like food, predation and diseases affect evolution. In this genetics lesson, students use red and white beans to simulate the effect of malaria on allele frequencies. They analyze data collected from the experiment and answer analysis questions at the end of the lab.
Fourth graders study sickle-cell anemia.
Pupils study sickle cell anemia and other genetic disorders.  In this investigative lesson students create a poster and present it to the class on a certain disorder. 
Students solve problems like the following examples: 1. If you have 10,000 women, age 30, who have babies and one in 900 of these births will result in a Down syndrome baby, how many will have this disease? 2. 5,000 babies are born; 2,000 to women age 20, 3,000 to women age 40. How many of each group will give birth to a Down syndrome baby?
If you are looking for a great way to present natural selection in humans, look no further. This handout is intended to accompany the 14-minute video The Making of the Fittest: Natural Selection in Humans, which can be found on the publisher's website. Before watching the video, learners read a page of information about sickle cell disease, then answer questions about sickle cell disease, and about the progress of science as a social process. Next, the video is shown, with pupils answering several higher-level thinking questions about concepts presented in the video. 
Students explore genetics through various hands-on activities. In this biology lesson, students predict the probability of offspring genotypes and phenotypes using the Punnett Square. They explain the causes of genetic abnormalities.
Nine pages of material on inheritance make up this handout. It begins with a reading on alleles and how they can result in albinism. A chromosome modeling activity and questions follow. Junior geneticists learn to complete Punnett squares and participate in a coin toss simulation of allele pairing. They also learn about sex determination, sickle-cell anemia, and pedigree analysis. This resource provides a variety of activities and information to support several days worth of genetics instruction.
Imagine a pair of dragons that produce offspring and determine the percentage of the hatchlings have wings and large antlers. This fantastic activity draws genetics learners in, introduces them to alleles, meiosis, phenotypes, genotypes, and teaches them how to use Punnett squares. The exercises also illustrate the law of independent assortment and linked genes. The handout is ten pages long and will take days to work through, but it will definitely keep learners engaged!
Can gene therapy treat sickle cell anemia? Genetics geniuses draw a Punnett square for this painful disease and then view a video about current gene therapy research. Then they discuss ethical questions related to this type of treatment. To close, they work with a sickle cell nucleotide sequence to complete the complementary sequence, the mRNA sequence, and corresponding amino acids. This video contains a touching and enlightening story of a family affected by sickle cell, and the lesson is a commendable curriculum piece for your genetics unit.
Eighth graders explore human health by researching a specific genetic disorder. In this illness presentation lesson, 8th graders must research a genetic disorder topic using the Internet and medical help before creating a video or poster presentation. Students create their presentations over 4 days while collaborating in groups.
After studying DNA replication and the genetics of inheritance, this slide show is useful for explaining specific mutations that can happen and result in an illness. Sickle cell anemia, and cystic fibrosis are explained on a genetic level. This slide could be used to start research about various other mutations that lead to illness, or maybe mutations that do not affect the quality of life.
Young scholars read, write and reflect on Science articles, this approach will promote both literacy and critical thinking skills. Critical thinking skills learned in the science classroom from these activities will impact students in many ways and help them make choices about issues they will confront in their daily lives.
Translate the process of protein synthesis to your molecular biologists with this instructional activity. It consists of reading, completing a table as a summary, comprehension questions, and a modeling activity for both transcription and translation. To conclude, the concepts are applied to the formation of sickle-cell hemoglobin. The worksheet actually makes a thorough lesson for introducing protein synthesis.
High schoolers analyze different types of hemoglobin. They use the technique of agarose gel electrophoresis to separate human hemoglobin molecules according to their electrical charge, size, and/or shape. Students relate the migration of hemoglobin molecules on the gel (phenotype) to the alleles possessed by individuals in the scenario (genotypes).
Students research about different genetic disorders. In this biology lesson, students create a poster highlighting facts about the disorder. They present their findings in class.
Students explore the causes of disease, how organisms, spread disease, and the process of infection. Examples of inherited diseases, environmentally caused diseases, and the agents that cause them are examined in this lesson.
A two-page worksheet provides seven Punnett squares for practice in determining genotypes and phenotypes. Each is an example of incomplete dominance or codominance. After your bright biologists have mastered Punnett squares, this will take them to the next step. Assign it as homework or use it as an assessment after some time have been invested in these genetics concepts.

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