{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='US scientists find how obesity gene works' data-url='/boclips/videos/5c54ca59d8eafeecae19b157' data-video-url='/boclips/videos/5c54ca59d8eafeecae19b157' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nUS scientists find how obesity gene works\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eScientists have finally figured out how the key gene tied to obesity makes people fat, a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise.For years, researchers have known that...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eScientists have finally figured out how the key gene tied to obesity makes people fat, a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise.For years, researchers have known that a particular gene called FTO was related to obesity, but they did not know how, and could not tie it to appetite or other known factors.Now experiments revealed that a faulty version of the gene causes energy from food to be stored as fat rather than burned. Genetic tinkering in mice and on human cells in the lab suggests this can be reversed, giving hope that a drug or other treatment might be developed to do the same in people.The work was led by scientists at the Massachusetts Institute of Technology (MIT) and Harvard University and published online on Wednesday by the New England Journal of Medicine.Obesity affects more than 500 million people worldwide and contributes to a host of diseases. In the United States about one-third of adults are obese and another third are more modestly overweight.Scientists have finally figured out how the key gene tied to obesity makes people fat, a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise.For years, researchers have known that a particular gene called FTO was related to obesity, but they did not know how, and could not tie it to appetite or other known factors.Now experiments revealed that a faulty version of the gene causes energy from food to be stored as fat rather than burned. Genetic tinkering in mice and on human cells in the lab suggests this can be reversed, giving hope that a drug or other treatment might be developed to do the same in people.The work was led by scientists at the Massachusetts Institute of Technology (MIT) and Harvard University and published online on Wednesday by the New England Journal of Medicine.Obesity affects more than 500 million people worldwide and contributes to a host of diseases. In the United States about one-third of adults are obese and another third are more modestly overweight.++AUDIO AS INCOMING++AP TELEVISIONBoston, Massachusetts - 19 August 20151. Various of pedestrians walking on street 2. SOUNDBITE (English) Manolis Kellis, Professor at the Massachusetts Institute of Technology (MIT):\"So what we have discovered is that at the root of the strongest genetic association with obesity lies a switch that works inside our fat cells - rather than in our brain - to control our appetite and what that switch does is that it decides whether the calories that we are gonna get from our food will be stored as fat or whether they will be burned away as heat.\"3. Kellis working in his home office4. SOUNDBITE (English) Manolis Kellis, Professor at the Massachusetts Institute of Technology (MIT):\"Everyone carries the genetic circuit that can switch our fat cells from storing energy to burning energy. That means that by intervening in the right genes in the way that we have uncovered in this particular publication, we can actually tune the metabolism of individuals who are obese - whether or not this obesity has a genetic root at all - and change the equation of the obesity epidemic across the global population.\"5. Various of Kellis pointing at illustrations of obesity study on computer screen6. SOUNDBITE (English) Manolis Kellis, Professor at the Massachusetts Institute of Technology (MIT):\"And this is very fundamental. It basically means that we now have the ability within our lifetime to consider therapeutic changes for obesity. To consider this third path beyond nutrition and beyond exercise by actually changing our metabolism directly. And that is a game changer in the field of obesity.\"7. Various of Kellis pointing at illustrations of obesity study on computer screen8. SOUNDBITE (English) Manolis Kellis, Professor at the Massachusetts Institute of Technology (MIT):\"The version of the FTO region that predisposes individuals to obesity is found in 44 percent of Europeans, 42 percent of southeast Asians and only five percent of Africans. This is, obviously, not the only region that predisposes individuals to obesity and it is, obviously, not the only cause of obesity, which has both a genetic component and a big environmental component associated with nutrition, lifestyle, and access to these high-energy foods.\"9. Kellis highlighting illustrations of the genetic code and processes influencing the ability of cells to transform excess energy into body fat or body heat10. SOUNDBITE (English) Manolis Kellis, Professor at the Massachusetts Institute of Technology (MIT):\"Our discovery does not mean that we can stop watching our diet or exercise. We think of this as a third pillar that we can rely on to combat obesity worldwide. We have to watch our health, we have to watch our lifestyle, we have to watch our diet, but in addition we now have the possibility of a therapeutic intervention that acts directly in our fat cells as a complement to the efforts that people make in their lifestyle, which have, unfortunately, very often fallen short.\"11. 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