{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-572d6a42.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-f4d0de30.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Which Will Kill You First?' data-url='/boclips/videos/60665fd63c9f286c5d9e6bc2' data-video-url='/boclips/videos/60665fd63c9f286c5d9e6bc2' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nWhich Will Kill You First?\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30358007\" href=\"/search?publisher_ids%5B%5D=30358007\"\u003eMinuteEarth\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eGet Surfshark VPN at and enter code MINUTEEARTH for 83% off and 3 extra months free! The body can get a whole lot colder - but not a whole lot hotter - before we die. Why is that? LEARN MORE ************** To learn more about this topic,...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eGet Surfshark VPN \u003ca href='https://surfshark.deals/minuteearth' target='_blank' rel='nofollow'\u003eat\u003c/a\u003e and enter code MINUTEEARTH for 83% off and 3 extra months free! The body can get a whole lot colder - but not a whole lot hotter - before we die. Why is that? LEARN MORE ************** To learn more about this topic, start your googling with these keywords: Hyperthermia: a medical condition where an individual's body temperature is elevated beyond normal Hypothermia: a medical doncition that occurs when an individual's body loses heat faster than it can produce heat, causing a dangerously low body temperature Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different Denaturation: the alteration of a protein shape through some form of external stress (for example, heat), so that it can no longer carry out its cellular function If you liked this week’s video, you might also like: A great article from Outside on \u003ca href='https://www.outsideonline.com/2398105/heat-stroke-signs-symptoms' target='_blank' rel='nofollow'\u003ehyperthermia\u003c/a\u003e Learn more about the woman who survived the lowest known body \u003ca href='https://www.atlasobscura.com/articles/the-woman-who-survived-the-lowest-body-temperature-ever' target='_blank' rel='nofollow'\u003etemp\u003c/a\u003e SUPPORT MINUTEEARTH ************************** If you like what we do, you can help us!: - Become our \u003ca href='https://patreon.com/MinuteEarth' target='_blank' rel='nofollow'\u003epatron\u003c/a\u003e - Share this video with your friends and family - Leave us a comment (we read them!) CREDITS ********* Kate Yoshida | Script Writer, Narrator and Director Sarah Berman | Illustration, Video Editing and Animation Nathaniel Schroeder | Music MinuteEarth is produced by Neptune Studios \u003ca href='https://neptunestudios.info' target='_blank' rel='nofollow'\u003eLLC\u003c/a\u003e OUR STAFF ************ Sarah Berman • Arcadi Garcia Rius David Goldenberg • Julián Gustavo Gómez Melissa Hayes • Alex Reich • Henry Reich Peter Reich • Ever Salazar • Kate Yoshida OUR LINKS ************ \u003ca href='https://youtube.com/MinuteEarth' target='_blank' rel='nofollow'\u003eYoutube |\u003c/a\u003e \u003ca href='https://tiktok.com/@minuteearth' target='_blank' rel='nofollow'\u003eTikTok |\u003c/a\u003e \u003ca href='https://twitter.com/MinuteEarth' target='_blank' rel='nofollow'\u003eTwitter |\u003c/a\u003e \u003ca href='https://instagram.com/minute_earth' target='_blank' rel='nofollow'\u003eInstagram |\u003c/a\u003e \u003ca href='https://facebook.com/Minuteearth' target='_blank' rel='nofollow'\u003eFacebook |\u003c/a\u003e \u003ca href='https://minuteearth.com' target='_blank' rel='nofollow'\u003eWebsite |\u003c/a\u003e Apple \u003ca href='https://podcasts.apple.com/us/podcast/minuteearth/id649211176' target='_blank' rel='nofollow'\u003ePodcasts|\u003c/a\u003e REFERENCES ************** Lepock JR (2004). Role of nuclear protein denaturation and aggregation in thermal radiosensitization, International Journal of Hyperthermia, 20:2, 115-\u003ca href='https://www.tandfonline.com/doi/abs/10.1080/02656730310001637334' target='_blank' rel='nofollow'\u003e130,\u003c/a\u003e Leuenberger, P, Ganscha S, Kahraman A, Cappelletti V, PJ Boersema, Mering Cv, Claassen M, Picotti P (2017). Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability Science, 355: \u003ca href='https://science.sciencemag.org/content/355/6327/eaai7825' target='_blank' rel='nofollow'\u003eeaai7825.\u003c/a\u003e Roti Roti J (2008) Cellular responses to hyperthermia (40–46 degrees C): cell killing and molecular events. International Journal of Hyperthermia 24(1): 3–\u003ca href='https://www.tandfonline.com/doi/full/10.1080/02656730701769841' target='_blank' rel='nofollow'\u003e15.\u003c/a\u003e Sawka MN, Leon LR, Montain SJ, Sonna LA (2011). Integrated physiological mechanisms of exercise performance, adaptation, and maladaptation to heat stress. Comprehensive Physiology 1: 1883-\u003ca href='https://onlinelibrary.wiley.com/doi/abs/10.1002/cphy.c100082' target='_blank' rel='nofollow'\u003e1928.\u003c/a\u003e Slovis CM, Anderson GF, Casolaro A (1982). Survival in a heat stroke victim with a core temperature in excess of 46.5 C. 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