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\nChaperone-Mediated Autophagy (CMA) | Selection, Mechanism and Regulation\n

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\n\nPublisher:\n\nJJ Medicine\n\n\n
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\nLesson on chaperone-mediated autophagy (CMA). CMA is a selective degradation process involving the use of protein chaperones, which target and deliver KFERQ-containing protein cargo to the lysosome for degradation. The chaperone complex...\nLesson on chaperone-mediated autophagy (CMA). CMA is a selective degradation process involving the use of protein chaperones, which target and deliver KFERQ-containing protein cargo to the lysosome for degradation. The chaperone complex in CMA consists of a variety of proteins including Hsc70 and Hsp90, which have important functions for CMA. CMA function requires not only proper chaperone functioning, but also lysosomal functioning. Decreased lysosomal functioning due to decreased lysosomal acidification, results in suppression of CMA. When the CMA chaperone complex delivers the protein cargo to the lysosome, the protein cargo is bound, unfolded and then translocated through a lysosomal membrane receptor known as LAMP2A. The protein cargo is then degraded within the lysosome via proteases known as cathepsins. LAMP2A is indispensable for CMA functioning and a deficiency of LAMP2A can lead to a condition known as Danon disease.

Hey everyone. Here is another lesson on autophagy - this time it is on chaperone-mediated autophagy (CMA). In this lesson, you will learn the differences between CMA and macroautophagy, when CMA is active and inactive, and how CMA “selects” its protein cargo through the KFERQ consensus sequence and what the KFERQ sequence is. You will also learn about the roles and purposes of each of the proteins in the chaperone complex, and you will learn the importance and role of various lysosomal proteins in CMA functioning. Finally, you will briefly learn about the genetic condition known as Danon disease, which is due to a deficiency in LAMP2A receptor.\n
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Resource Details

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Educator Rating
Not yet Rated
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Media Length
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11:44
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Grade
Higher Ed
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Subjects
Science
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Media Type
Instructional Videos
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Source:
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\nJJ Medicine\n\n
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Date
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2017
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Language
English
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Audiences
For Teacher Use
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Usage Permissions
Fine Print: Educational Use
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Concepts

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amino acids, protein, translocation
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Additional Tags

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chaperone mediated autophagy, autophagy, chaperone-mediated autophagy, cma autophagy, chaperone mediated autophagy and macroautophagy, macroautophagy, macroautophagy and cma, cma and hsc70, cma and hsp90, chaperone autophagy, lysosomal autophagy, lamp2a, autophagy lesson, chaperone-mediated autophagy lesson, chaperone-mediated autophagy and health, chaperone-mediated autophagy and disease, autophagy animation, autophagy fasting, soluble protein, western diet, prolonged starvation, working properly, lysosomal membrane, cma function, lysosomal function, consensus sequence, chaperone complex, important function, membrane protein, danon disease, lamp 2c, important protein, protein cargo, function, chaperone, important, sequence, cargo, degradation, lamb, process, disease, involved, lesson, lamp
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Best For: Explaining a topic
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