BC Open Textbooks
Concepts of Biology – 1st Canadian Edition
How diverse are living things? Individuals explore topics such as cells as the foundation for life, cell division and genetics, molecular biology, and animal reproduction using an open resource Biology textbook. They learn key terms...
Howard Hughes Medical Institute
Molecular Genetics of Color Mutations in Rock Pocket Mice
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Howard Hughes Medical Institute
The Molecular Evolution of Gene Birth and Death
More than 90 percent of humans' DNA doesn't code for anything! Scholars watch a presentation as they answer questions relating to gene mutations. They read details, watch videos, and view animations supporting the concepts. The questions...
Howard Hughes Medical Institute
How Do Fibers Form?
The proteins inside a cell determine the shape of the cell. While most red blood cells have a circular shape, those with sickle cell take the shape of a sickle. This change in shape causes multiple issues in the system. Scholars solve...
Howard Hughes Medical Institute
Population Genetics, Selection, and Evolution
The Hardy-Weinberg principle states that alleles and genotypes remain constant in the absence of evolutionary influences. Scholars complete a simple hands-on activity applying the Hardy-Weinberg principle to sample data. They observe how...
Cold Spring Harbor Laboratory
Mutations Are Changes in Genetic Information
A red delicious apple tree with a simple mutation means we now benefit from the existence of golden delicious apples. Learn how simple mutations change genetic information in DNA sequences. Using biographies, videos, and animations,...
Howard Hughes Medical Institute
Classroom Activities: Stem Cells and Diabetes
How close are we to a cure for diabetes? It seems the cure which has a connection to stem cell research is a possibility! Learners explore the concept of stem cells with an engaging hands-on activity. A PowerPoint presentation provides...
Serendip
Understanding the Biology of Cancer
After initial exposure to a carcinogen, a cancer diagnosis often takes more than a decade due to the slow buildup of mutated cells in the body. Scholars learn about the biology of cancer with a worksheet and discussion questions. They...
Serendip
The Molecular Biology of Mutations and Muscular Dystrophy
Different types of mutations cause unique types and degrees of muscular dystrophy. Scholars learn about the types of mutations and the impact on the body. They compare the location of the mutations and draw conclusions about how it is...
Howard Hughes Medical Institute
Lactose Intolerance: Fact or Fiction
Around the world, about 2/3 of adult humans are lactose intolerant. Scholars work in small groups to discuss a few statements about lactose intolerance. Then, they watch a video on the topic and readdress each statement. Whole-class...
Howard Hughes Medical Institute
Using Genetic Crosses to Analyze a Stickleback Trait
Two fish appear different, but how do scientists determine their genotypes? Scholars practice performing test crosses to determine the genotypes of fish given their phenotypes. They answer in-depth comprehension questions and complete...
Howard Hughes Medical Institute
Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish
Gene switches work similarly to light switches in controlling one feature of their environments. Scholars study the Pitx1 gene in a specific type of fish. They learn the different ways this switch controls various body parts and...
Howard Hughes Medical Institute
Mendelian Genetics, Probability, Pedigree, and Chi-Square Statistics
People with the sickle cell trait, but not sickle cell disease, find natural protection against malaria. Scholars consider various combinations of genotypes and environmental factors to determine if children might have sickle cell...
Serendip
Soap Opera Genetics – Genetics to Resolve Family Arguments
Did she cheat on her husband? Did the hospital switch the babies? Should they have children? As much as this sounds like the plot for a soap opera, all of these questions fit into a single lesson on genetics. Scholars read about three...
Serendip
Mitosis, Meiosis and Fertilization Vocabulary Review Taboo Game
Can you describe a gamete without using the words sperm or egg? Scholars play a vocabulary review game where they try to get other players to guess their words. Each card has the target word as well as two related words they must not...
Serendip
UV, Mutations, and DNA Repair
How effective are cells at repairing UV damage? An inquiry-based lesson has learners experiment with organism by exposing them to various levels of UV light and then examining their DNA after a period of time. Pupils test different...
Howard Hughes Medical Institute
The Eukaryotic Cell Cycle and Cancer
How does cancer begin, and why can it get so out of control? Curious young cytologists use an interactive resource to study the cell cycle. After reviewing the background information, individuals go step-by-step through the process of...
Howard Hughes Medical Institute
Lactase Persistence: Evidence for Selection
What's the link between lactase persistence and dairy farming? Biology scholars analyze data to find evidence of the connection, then relate this to human adaptation. Working individually and in small groups, learners view short video...
Howard Hughes Medical Institute
Viral DNA Integration
How do reverse transcriptase inhibitors work? Young virologists examine the function of azidothymidine, a drug doctors use to treat HIV patients, during a hands-on modeling activity. Groups create a strand of DNA from an HIV RNA strand...
Howard Hughes Medical Institute
Developing an Explanation for Mouse Fur Color
Whether or not you think mice are nice, you'll love the colorful activity! Scholars examine evidence for evolution in the rock pocket mouse through video, discussion, and collaborative work. Learners watch a video regarding variation in...
Howard Hughes Medical Institute
Central Dogma and Genetic Medicine
Scientists work every day to find solutions to genetic diseases. Scholars learn about the process of gene sequencing, mutations, and the results. They explore genetic diseases and therapies to intervene and help and, through case...
Howard Hughes Medical Institute
The Teosinte Hypothesis
Don't want to sound corny, but your class will be a-maize-d by an engaging activity! Explore the history of the modern corn plant through a video and Punnett squares. Junior genetics experts get hands-on experience with actual research...
Towson University
Looking Into Lactase: Structured Inquiry
Why is lactase important? Biology scholars explore enzyme function in a structured inquiry lab. The activity tasks lab groups with observing how temperature and pH affect enzyme activity, as well as determining which milk products...
CK-12 Foundation
Meiosis
"We Are Never Ever Getting Back Together" makes the perfect theme song for meiosis. The simulation encourages scholars to move the chromosomes and chromatids to properly illustrate the meiosis break up. Multiple-choice questions allow...