Curated OER
The Cloning of Plasmid and Spinach DNA
Students will first extract genomic DNA from spinach and perform a restriction enzyme digestion on both the spinach DNA and the plasmid using the same restriction enzyme. They then ligate the cut plasmid DNA with the cut spinach DNA in...
Curated OER
Cloning of Plasmid and Spinach DNA
Students ligate fragments of genomic DNA from spinach into a vector plasmid. They perform a restriction enzyme digestion. Student use a ligated DNA molecule to transform E. coli cells. Students analyze their procedures and outcome of...
Curated OER
DNA Sequencing Model Lab
Students pretend they are each genetic engineers with a test tube of unknown DNA (PCR'd) possibly taken from blood cells of someone with a genetic condition.
Curated OER
DNA Fingerprinting
Ninth graders investigate what restriction enzymes do, and explain how a DNA sample can link a suspect to a crime.
Curated OER
Genetics 5 Technology
Students, after studying extraction and gel electrophoresis, recombinant DNA, transgenic organisms, and reproductive cloning, summarize the main concepts in DNA technology. They analyze the applications of DNA: forensics, medicine,...
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Molecular Evolution in Plants
High schoolers are using a paper chromatography study that is suitable for introductory biology. The absorption spectra studies and gel electrophoresis studies are appropriate for students who have complete both introductory biology and...
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Using VNTR Analysis to Identify Guilt at a Crime Scene
Students collect DNA from cheek cells. They compare and contrast the processes of DNA replication and PCR. They discuss how this information can be used to determine guilt at crime scenes.
Curated OER
"Who Done It?" Analysis of Molecular Fingerprints Left At the Scene of the Crime
Learners examine different types of DNA fragments. They record and analyze their results. They determine who is the criminal in the story.
Curated OER
Who Done It?
Students work in groups to solve various murder mysteries using DNA evidence to implicate suspects. Teams compete to solve the crimes the fastest, while using various scientific methods to accomplish their task.
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Doggy DNA: The Power of PCR
Pupils listen as the teacher lectures about Polymerase Chain Reaction, and the technical information about its uses. They collect dog saliva and run/analyze a gel electrophoresis. Students use a computer to integrate information, and...
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Determination of Phylogenetic Relationships Using Restriction Analysis
Students applied various mathematical analyses to interpret their data. By using the resulting DNA fragment patterns from several enzymes students established a possible evolutionary relationship among the mice.
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Molecular Explorations
Students explain the processes for separating DNA from tissue and separating complex mixtures. In this exploratory lesson students complete a lab where they extract DNA.
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Sequencing
Learners gather information about gene sequencing. In this biology lesson, students use the Internet to access information about gene sequencing, then work in pairs to read and record a gene sequence. Lesson includes extension activities.
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Island Biogeography and Evolution: Solving a Phylogenetic Puzzle With Molecular Genetics
Students engage in solving a logic problem based on real organisms and real data. They develop phylogenies for seven related populations of lizards living on the Canary Islands.
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Cut-Off Genes
Students explain the concept of gene sequence analysis. In this gene lesson, students draw inferences about phylogenetic similarities of different organisms.
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Sequencing the Cystic Fibrosis Gene: A Simulation
Ninth graders use this activity to simulate the sequencing of gene and to detect the presence of possible genetic defects. They use diagrams that represent bands of nucleotides in order to determine the sequence of a small piece of the...
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Proteins Expressed At Different Stages
Young scholars investigate protein electrophoresis in a lab setting. Full laboratory equipment is needed and safety should be taught. The level of prior knowledge needed to perform lab is high and is ideal for an honors class.
Curated OER
Restriction Enzymes
Students explore enzymes and enzyme combinations. They examine and cut up and practice matching DNA sequences.
Curated OER
Genetics
An interesting PowerPoint which provides the main facts, definitions, and terminology necessary for understanding DNA. It also presents summaries of the processes involved with DNA replication and the application of protein isolation and...
Curated OER
Pour and Load Agarose Gels
Students practice pouring an agarose gel and loading the DNA into the wells to perform a genetic analysis of variation among individuals and between populations. They electrophorese the gel overnight.
Virginia Department of Education
Biotechnological Issues and Bioethics
Culminate a bioethics unit with the implementation of a lesson plan that incorporates the Socratic method to encourage class feedback and participation. Pupils participate in a discussion on bioethics and morality, complete a writing...
Virginia Department of Education
Adaptation and Evolution
Um may be the atomic symbol for confusion, but it won't be needed in this instructional activity. Scholars rotate through seven stations completing experiments, hands-on activities, writing exercises, and analysis. Stations include...
Curated OER
Molecular Approaches to Evolution
Students are introduced to working with molecular data. The first activity does both simulated and original data are used to compare amino acid, protein or DNA differences to construct phylogenetic trees or cladograms. These activities...
Curated OER
Sequencing the Cystic Fibrosis Gene: A Simulation
Ninth graders determine nucleotide sequences. They identify those base sequences that are normal, those that are normal variants and those that cause cystic fibrosis. Students use DNA nucleotide sequences to determine amino acid...