Howard Hughes Medical Institute
Drug Adherence and Resistance
The FDA approved more than 25 drugs to treat HIV—and often people must use them in combination. One of the largest challenges with these medications happens due to patient error. Class members use an interactive to learn about drug...
Howard Hughes Medical Institute
Human Feet Are Strange
Feet are neat! So, if you've already walked the path of examining animal footprints with your class, put them in the shoes of early humans! A well-designed activity incorporates video, discussion, and hands-on learning to demonstrate how...
Howard Hughes Medical Institute
CSI Wildlife
Can DNA fingerprinting prevent the extinction of elephants? Young scientists learn about DNA fingerprinting before applying their knowledge to case studies of elephant poaching. The first case requires them to match the DNA from a tusk...
Howard Hughes Medical Institute
Population Dynamics
Will human population growth always be exponential, or will we find a limiting factor we can't avoid? Young scientists learn about both exponential and logistic growth models in various animal populations. They use case studies to...
Howard Hughes Medical Institute
Gorongosa: Making Observations Activity
Do you have young scientists wanting to make new discoveries rather than just completing the same experiments? Young scientists use their observational skills to identify animals and patterns in animal behavior. Through tracking...
Howard Hughes Medical Institute
EarthViewer
Can you imagine Washington DC and London as close neighbors occupying the same continent? Learners will be fascinated as they step back in time and discover the evolution of the earth's continents and oceans from 4.5 billion years ago to...
Howard Hughes Medical Institute
Using DNA to Explore Lizard Phylogeny
In a fun and interactive two-day lesson, learners sort anole lizard pictures by appearance. Next, they watch a video about the anoles and re-sort based on the information in the video. In addition to physical characteristics, budding...
Howard Hughes Medical Institute
The Making of the Fittest: The Birth and Death of Genes
After watching an engaging 13-minute video about the colorless blood of icefish, future ichthyologists examine icefish blood and non-icefish blood (blood samples are simulated with Karo syrup mixtures) to determine advantages of...
Howard Hughes Medical Institute
The Making of the Fittest: Natural Selection in Humans
Sickle cell disease only occurs when both parents contribute the trait, and mostly in those of African descent. Where did it come from? How did it evolve? Tony Allison, a molecular biologist, noticed a connection between sickle cell and...
Howard Hughes Medical Institute
The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture
Got milk? Only two cultures have had it long enough to develop the tolerance of lactose as an adult. Learn how the responsible genes evolved along with the cultures that have been consuming milk. This rich film is supplied with a few...
Howard Hughes Medical Institute
The Making of the Fittest: Natural Selection and Adaptation
The pocket mouse can be light brown like the sands of the desert, or dark brown like the volcanic lava flows that are interspersed throughout New Mexico's Valley of Fire. It seems that predators have weeded out light colored mice in this...
Howard Hughes Medical Institute
Classroom Activities: Stem Cells and Diabetes
A multi-faceted instructional activity immerses AP biologists into the world of the stem cell. Using PowerPoint presentations, you introduce your class to diabetes and the possibility of finding cures through stem cell research. Online...
Howard Hughes Medical Institute
How Novel Icefish Genes Can Improve Human Health
Designed to accompany the 13-minute video The Making of the Fittest: The Birth and Death of Genes, this handout serves as both a viewing guide during the video and an analysis of how the adaptations of the icefish might help treat some...
Howard Hughes Medical Institute
Got Lactase? The Co-Evolution of Genes and Culture
Does the human body evolve as quickly as human culture? With a stellar 15-minute video, explore the trait of lactose intolerance. Only about 1/3 of human adults seem to still have the enzyme lactase and therefore, the ability to digest...
Howard Hughes Medical Institute
The Making of the Fittest: The Birth and Death of Genes
Adaptations must be made as environments change. This fabulous presentation features Icelandic icefish, a transparent, scaleless specimen that even has colorless blood. Genetics and adaptations concepts are explored as scientists study...
Howard Hughes Medical Institute
Survival of the Fittest - Variations in the Clam Species Clamys sweetus
It's not often that you come across a clever laboratory activity that is both imaginative and comprehensive! Using M&M's and Reese's peanut butter candies to represent two different clam species, young biologists test for "relative...
Howard Hughes Medical Institute
Microarrays and Stem Cells
Background reading is available in the first two pages of this worksheet, along with reading comprehension questions and a laboratory activity in which students use mircroarray technology to identify genes used in cell differentiation....
Howard Hughes Medical Institute
Icefish Blood Adaptations: Antifreeze Proteins
Ever wonder how fish survive in freezing cold water—especially Antarctic waters? Some fish have an adaptation that lowers the freezing point of their life fluids. Learners model these adaptations in two lab explorations. The first...
Howard Hughes Medical Institute
Classroom Activities: What Is My Carbon Footprint?
Everyone leaves an impression on the world—some more than others. An interactive lesson has learners analyze their lifestyles and the impact they have on the environment. The analysis includes travel, food, and energy categories and ends...
Howard Hughes Medical Institute
Color Variation Over Time in Rock Pocket Mouse Populations
Simple characteristic changes can have a significant impact on species survival. A hands-on activity has learners investigate the color variation in pocket mouse populations in different environments. They connect the timing and number...
Howard Hughes Medical Institute
Climate and Earth Systems
The components of the atmosphere have a significant impact on long-term climate change. Learners begin by analyzing the role of carbon dioxide in the earth systems and how varying the levels would affect those systems—and ultimately...
Howard Hughes Medical Institute
Pulse Chase Primer: The Meselson-Stahl Experiment
Experimental design can make or break an experiment. Young scholars analyze the pulse-chase analysis procedure by studying the Meselson-Stahl experiment. Using a video presentation, they discover how the pulse-chase analysis led to the...
Howard Hughes Medical Institute
Discovering the Wallace Line
When studying locations of specific species, interesting patterns emerge. Young scholars discover this as they plot the location of specific species on a group of islands. Patterns emerge as they identify the Wallace Line. They then...
Howard Hughes Medical Institute
Fact Patterns: A Film Guide
What does it take to create a scientific theory? Learners attempt to answer the question by studying the work of Charles Darwin and Alfred Russel Wallace. While watching a video, they track observations from each scientist and then look...