Catalyst University
Catalytic Mechanism of Myeloperoxidase & Hypochlorous Acid Functions
Here we explore the catalytic mechanism of Myeloperoxidase and subsequent formation of Hypochlorous Acid and Hypothiocyanite, two reactive oxidative species (ROS). We will also see functions of Hypochlorous Acid.
Professor Dave Explains
Edward Jenner and the Dawn of Immunology
Now that we are past the Renaissance and approaching a more modern era, it's time to quickly touch upon a major advancement in battling pathogens. Edward Jenner invented the smallpox vaccine, which was responsible for eradicating the...
Professor Dave Explains
The Complement System: Classical, Lectin, and Alternative Pathways
We are learning about the features of innate immunity, and one that is often overlooked is the complement system. This is a very complicated ensemble of proteins circulating in the bloodstream that activate each other in a specific...
Professor Dave Explains
Pattern Recognition Receptors
We've already introduced pattern-recognition receptors, which recognize PAMPs and DAMPs, but now let's go over the specific types, and how they work. How many Toll-like receptors are there and what do they recognize? What are the adaptor...
Catalyst University
Flattening the Curve | What Does it Really Mean?
This dissects in detail the meaning of the phrase, " Flattening the Curve", with respect to the COVID-19 pandemic.
Catalyst University
Clonal Selection EXPLAINED
In this video, we discuss the basic idea of clonal selection.
Professor Dave Explains
The Inflammasome
When you get a bacterial infection, the immune response needs to be very rapid. But it can take hours to sense a threat, and generating effector proteins in response takes time. Luckily, we all have large protein complexes called...
Catalyst University
Classical Pathway of Complement Activation
Classical Pathway of Complement Activation
Healthcare Triage
The Flu is Terrible!
This year's influenza is really bad. Hospitalizations are up, and health departments in 49 states report widespread flu. Apparently, if you don't want the flu, go to Hawaii. Just kidding. You can still get a flu shot, and you don't have...
Next Animation Studio
Explainer: How the coronavirus (SARS-CoV-2) infects human cells
Researchers from China have used cryo-electron microscopy to show how the virus responsible for COVID-19 attacks humans.
Healthcare Triage
Get Your Flu Shot! It's Not About You, OK?
It's not too late to get a flu shot! You may have heard that the flu shot this year is "less effective" than in earlier years. That may not mean what you think it means. Less effective is a relative relationship, and in absolute terms,...
Professor Dave Explains
Structure and Immune Function of the Lymphatic System
With some basics out of the way, we are ready to get a sense of the overall structure of the immune system. That will mean looking at the lymphatic system. We already looked at this system in the context of its involvement in the...
Professor Dave Explains
Signal Transduction in Immune Cells: Receptor-Ligand Interactions
Now that we know some things about immune cell structure and function, we need to start understanding how these cells interact on the molecular level, and how signals are translated into cellular response. This means looking at...
Catalyst University
What is Herd Immunity? Does it Relate to COVID-19?
n this video, we will discuss the basic idea of herd immunity and what it means. Then, we will discuss the basic idea of a pathogen's basic reproduction number (R0) and how to predict the number of individuals who require immunization to...
Curated Video
EVERY Human Would Die Without This Cell
What if I told you that there’s one cell in your body that if you don’t have it, you will die? And I’m not saying you might die. I’m telling you that you WILL die if you don’t have it. What is it?
Catalyst University
The Coronavirus Replication Cycle
In this video, I explain how the Coronavirus (COVID-19) infects and replicates inside the host’s cells.
Catalyst University
Natural Killer Cells: How Do They Kill Selectively?
Natural Killer Cells: How Do They Kill Selectively?
Next Animation Studio
Experts explain what viruses are
Viruses straddle the definition of being living and nonliving, according to the National Human Genome Research Institute.
Professor Dave Explains
Introduction to Innate Immunity
By now we've introduced a number of elements of the immune system. Now it's time to start learning how these work together to recognize and eliminate pathogens. Let's start by taking a deep dive into the innate immune response. This...
Professor Dave Explains
The Immune System: Innate Defenses and Adaptive Defenses
There are so many critters out there, bacteria and viruses that want to wreak havoc in our bodies. How do we defend ourselves against such tiny threats? The immune system! This is quite possibly the most profoundly remarkable aspect of...
Professor Dave Explains
Introduction to Immunology
As we know from our understanding of microbiology, pathogens are everywhere. So why don't we get sick all the time? And what are allergies, why do some people have them and others don't? And what are vaccines, how do those work? All of...
Press Association
GOSH pilots AI assistant to give clinicians more quality-time with patients
Patients and clinicians at Great Ormond Street Hospital for Children are leading the first NHS trial of a bespoke healthcare AI assistant, TORTUS, to help improve face-to-face time during appointments. This programme is the first of its...