When it comes to science and medicine, ethics should always be a primary consideration; unfortunately, that has not always been the case. There are countless examples throughout history of questionable medical practices, marginalized ethnic groups being used for hideous experimentation, and even well-meaning doctors performing ongoing studies on patients without their knowledge or consent. The Tuskegee case described herein falls in the latter category, but still contains a wealth of racial, ethical, and moral dilemmas for your upper-level high schoolers to examine and debate. The instructional activity is recommended for more mature students because, in addition to the aforementioned issues, the case study is about syphilis and also contains a lengthy and dense reading.