Instructional Video

Gleevec-Resistant Form of Kinase BCR-ABL

Curated and Reviewed by Lesson Planet

Gene mutation occurs at a rate much higher than many realize. Doctors treating cancer and other illnesses must learn to adapt quickly after each mutation. Viewers observe an animation and watch lecture with props to see what happens when a gene mutates so one specific medication no longer works. They visually observe how a simple change in shape allows a new medication to work when the original stops.

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CCSS: Adaptable
Additional Tags
Instructional Ideas
  • Discuss when researchers should start looking for a new drug, immediately or after they see how the body might mutate
Classroom Considerations
  • Allows teachers to download the file in multiple sizes and formats
  • Relies on prior knowledge of ATP and genetic mutations
Pros
  • Designed to meet standards for both AP and IB Biology
  • Includes a transcript for ease of note taking
Cons
  • None