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High schoolers comprehend that karyotyping is a process in which chromosomes are cut from an enlarged picture and arranged in decreasing order of size. The cells to be viewed are first chemically treated to increase the number of dividing white blood cells and then treated with colchicines to stop mitotic division during anaphase. Lastly, the cells are burst open, stained and fixed. The slide is examined for well spread chromosomes, photographed, and karyotyped.