Howard Hughes Medical Institute
The Making of the Fittest: The Birth and Death of Genes
Adaptations must be made as environments change. This fabulous presentation features Icelandic icefish, a transparent, scaleless specimen that even has colorless blood. Genetics and adaptations concepts are explored as scientists study...
Howard Hughes Medical Institute
The Molecular Evolution of Gene Birth and Death
More than 90 percent of humans' DNA doesn't code for anything! Scholars watch a presentation as they answer questions relating to gene mutations. They read details, watch videos, and view animations supporting the concepts. The questions...
Virginia Department of Education
Genetic Variation and Mutations
Young scientists demonstrate their creativity while completing several activities, to assess genetic variations and mutations. Instructors provide a list of options and scientists choose to write a comic strip, create a book, construct a...
Cold Spring Harbor Laboratory
Master Genes Control Basic Body Plans
Have you ever been so tired you missed a major announcement? Eric Wieschaus woke to a call explaining he won the Nobel Prize, but he thought it was just a dream until Christiane Nusslein-Volhard, a co-winner, explained it to him later...
Agriculture in the Classroom
Design 'Y'er Genes
How do changes in DNA affect an organism? Scholars explore chromosomes, genes, DNA, and mutations by modeling the DNA of a strawberry. They build a DNA model, then manipulate it to show how changing the genes transforms the strawberry...
Curated OER
Genes, DNA, and Mutations
With paper DNA patterns, budding biologists model translation and base-pair substitution within sequences. Through these activities, they examine how mutations can result in genetic disorders. The modeling that occurs is an enlightening...
Curated OER
Evolution
Explore the concept of evolution and cell biology; your class can work in groups to use the internet to view websites on evolution, take a quiz, and complete a lab activity.
Curated OER
DNA Cut and Paste Activity
Here is a cut and paste activity worksheet designed for older students. They fill in the blank with information about the composition of DNA, then create a DNA strand with its complimentary nucleotide chain.
Howard Hughes Medical Institute
Molecular Genetics of Color Mutations in Rock Pocket Mice
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Curated OER
Gene to Protein
Mutation and auxotrophs are discussed. Next, the details of RNA transcription and how enzymes can control splicing and introns are given.
Beyond Benign
Lucky Brand Genes: Chromosome Cookies
Mutations are not just deformed creatures we see in movies—they happen every day! Scholars study the different types of genetic mutations in the 12th installment of a series of 18 lessons. A creative activity uses candy and other food...
Howard Hughes Medical Institute
Cancer Discovery Activities
Explore the genetic component of the second-leading cause of death in the world using a hands-on activity. After watching a video discussing the basics of cancer, learners complete activities that study the genes involved in cancer. The...
Howard Hughes Medical Institute
How Novel Icefish Genes Can Improve Human Health
Designed to accompany the 13-minute video The Making of the Fittest: The Birth and Death of Genes, this handout serves as both a viewing guide during the video and an analysis of how the adaptations of the icefish might help treat some...
Howard Hughes Medical Institute
Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish
Gene switches work similarly to light switches in controlling one feature of their environments. Scholars study the Pitx1 gene in a specific type of fish. They learn the different ways this switch controls various body parts and...
Serendip
The Molecular Biology of Mutations and Muscular Dystrophy
Different types of mutations cause unique types and degrees of muscular dystrophy. Scholars learn about the types of mutations and the impact on the body. They compare the location of the mutations and draw conclusions about how it is...
Howard Hughes Medical Institute
Got Lactase? The Co-Evolution of Genes and Culture
Does the human body evolve as quickly as human culture? With a stellar 15-minute video, explore the trait of lactose intolerance. Only about 1/3 of human adults seem to still have the enzyme lactase and therefore, the ability to digest...
Curated OER
Activity: Gummy Bear Genetics
Who's your Daddy ... and Mommy for that matter? Given a first-generation group of gummy bear offspring, young scientists must determine which bears are their parents. An activity instructional activity covers the differences in genotypes...
Curated OER
Cell Wall Recipe: A Lesson on Biofuels
Biotech engineers discover that changes in the DNA code for cell wall formation can help create crops better suited for biofuel production. They extract DNA from wheat germ. They decode paper strips with codes and relate the activity to...
Serendip
UV, Mutations, and DNA Repair
How effective are cells at repairing UV damage? An inquiry-based lesson has learners experiment with organism by exposing them to various levels of UV light and then examining their DNA after a period of time. Pupils test different...
Howard Hughes Medical Institute
Stalking the Genetic Basis of a Trait
Need an a-maize-ing lesson to show your class how regulatory genes work? If you use the well-written resource, they'll be all ears! Biology scholars discover the gene responsible for the evolution of the modern-day corn plant through a...
Howard Hughes Medical Institute
Lactase Persistence: Evidence for Selection
What's the link between lactase persistence and dairy farming? Biology scholars analyze data to find evidence of the connection, then relate this to human adaptation. Working individually and in small groups, learners view short video...
Curated OER
Mutations and Cancer
Students study how cancer cells mutate and affect cell division. In this investigative lesson students view a PowerPoint presentation learn the seven warning signs of cancer.
Curated OER
The Clark Family Story: Tracing the Cause of Hemophilia
Ms. Strohfeldt did not omit anything when she designed this comprehensive lesson plan on DNA mutation and sex-linked traits. Begin with a pretest as an anticipatory set. Read a case history of the Clark family and the occurrence of...
Howard Hughes Medical Institute
HIV Protease Inhibitors
How do doctors fight a virus that's constantly mutating? Show science scholars how we fight HIV using one of its own most fundamental processes through a thoughtful demonstration. The lesson focuses on how protease inhibitors prevent HIV...