Howard Hughes Medical Institute
DNA Profiling Activity
Everyone loves a good mystery ... can your class actually solve one? Partnered pupils take on the role of forensic investigators during a three-part activity focusing on DNA evidence processing. Learners discover the methods used to...
Cold Spring Harbor Laboratory
A Gene Is a Discrete Sequence of DNA Nucleotides
Frederick Sanger won two Nobel prizes for protein sequencing and DNA sequencing. Young scientists learn about Dr. Sanger's research and amazing discoveries. They read an article and a biography, view videos and animations, and apply...
Cold Spring Harbor Laboratory
A Gene Is Made of DNA
Does a protein or DNA store genetic instructions for life? Follow the research from the 1920's experiments on mice through the 1940's experiments on bacteria to learn the answer to the difficult question. Scholars use an online...
Cold Spring Harbor Laboratory
A Half DNA Ladder Is a Template for Copying the Whole
The experiment known as one of the most beautiful experiments in biology changed the way we think about DNA. Learn about the experiment and the scientists who designed it—as well as the scientists who built on the results—with an online...
Cold Spring Harbor Laboratory
The DNA Molecule Is Shaped like a Twisted Ladder
One of the first models of DNA appeared to be a triple helix. Young scientists learn about the many scientists who worked to find the shape of DNA. They observe multiple models, tests, and experiments to understand the conclusions. An...
Cold Spring Harbor Laboratory
DNA and Proteins Are Key Molecules of the Cell Nucleus
When DNA research first began, it required almost an entire day to extract the molecules from a cell nucleus. Now it requires less than an hour. Scholars learn about the early theories of DNA with an online interactive, videos,...
Cold Spring Harbor Laboratory
RNA Is an Intermediary Between DNA and Protein
For years, scientists believed tRNA was junk left over from larger RNA. Three scientists used different approaches to prove tRNA actually exists as the connection between DNA and protein. Learn about their experiments, their lives, and...
Cold Spring Harbor Laboratory
Bacteria and Viruses Have DNA Too
In the 1940s, scientists discovered bacteria conjugation, the process of DNA transfer or bacterial sex. The discovery proved that bacteria and viruses contain DNA and led to a Nobel prize. Interested individuals learn about the...
Cold Spring Harbor Laboratory
DNA Words Are Three Letters Long
DNA writes 64 different words but only codes for 20 different amino acids. Budding scientists learn about where each of these numbers come from and why they aren't equal with an online interactive. The resource explains the research, the...
Cold Spring Harbor Laboratory
Some DNA Can Jump
Some people have a natural ability to jump, but did you know DNA also naturally jumps? Learn about the fun habit by looking at the research of a pioneering female scientist. Barbara McClintock fought prejudice and surpassed her mentors...
Cold Spring Harbor Laboratory
Some DNA Does Not Encode Protein
Roy John Britten easily earned a PhD in nuclear physics—but he found painting with water colors too difficult. Young scientists learn about Britten's life, career, and research with an online interactive. They read a biography, view...
Cold Spring Harbor Laboratory
DNA Is Packaged in a Chromosome
Roger Kornberg, the oldest son of two biochemists, won the 2006 Nobel Prize in Chemistry. Learn about Kornberg and his scientific research with an animation, videos, biography, and an applied problem-solving activity. A summary and...
Howard Hughes Medical Institute
CSI Wildlife
Can DNA fingerprinting prevent the extinction of elephants? Young scientists learn about DNA fingerprinting before applying their knowledge to case studies of elephant poaching. The first case requires them to match the DNA from a tusk...
Cold Spring Harbor Laboratory
Genes Can Be Moved Between Species
Biotechnology changes lives every day, but how did it all start? Learn about Cohen and Boyer's technique for recombinant DNA and the founding of this new scientific study. Then, scholars use the online interactive to discover how Hanahan...
Cold Spring Harbor Laboratory
DNA Responds to Signals from Outside the Cell
How do cells know when to replicate, transcribe, and stop? James E. Darnell, Jr. shifted from studying medicine to biochemistry and decided to address this mystery. Learn about his research, discoveries, and the impact on future medical...
Cold Spring Harbor Laboratory
DNA Is Only the Beginning for Understanding the Human Genome
Mario Capecchi requested funding for a new procedure targeting genes and was rejected. Four years later, after he proved it worked, the NIH apologized and funded his research. Use an online interactive to learn about his research and the...
Cold Spring Harbor Laboratory
Mutations Are Changes in Genetic Information
A red delicious apple tree with a simple mutation means we now benefit from the existence of golden delicious apples. Learn how simple mutations change genetic information in DNA sequences. Using biographies, videos, and animations,...
Cold Spring Harbor Laboratory
Some Types of Mutations Are Automatically Repaired
Does natural light damage or repair DNA? Learn the answer discover the scientists who researched the topic with an online interactive. Scholars read through an online animation presenting the content at their own pace. Then, they read...
University of California
Migration of Early Humans: Evidence and Interpretations
While much of prehistory is cloaked in mystery, ancient ancestors left evidence in DNA, languages, and materials from their time. Using photographs of items such as cave paintings and ancient tools, as well as maps of linguistic patterns...
Cold Spring Harbor Laboratory
Living Things Share Common Genes
Everything evolved from a common ancestor, but how did modern plants and animals develop so many more genes? Scholars use an online interactive to learn about the process. They begin to understand common genes with an animation, multiple...
Serendip
Genetic Engineering Challenge – How Can Scientists Develop a Type of Rice That Could Prevent Vitamin A Deficiency?
Brown rice contains vitamins B and E, while white rice lasts longer in storage. The availability of rice around the world makes it a great candidate for genetic engineering. Scholars apply their knowledge of genetic engineering to solve...
Howard Hughes Medical Institute
Natural Selection and the Evolution of Darwin's Finches
Darwin explained the connection between species of finches 150 years before scientists understood DNA. Technology and progressing science proved he was right, yet many struggle to understand how natural selection happens. Scholars use...
Howard Hughes Medical Institute
Central Dogma and Genetic Medicine
Scientists work every day to find solutions to genetic diseases. Scholars learn about the process of gene sequencing, mutations, and the results. They explore genetic diseases and therapies to intervene and help and, through case...
Cold Spring Harbor Laboratory
The RNA Message Is Sometimes Edited
In 1993, Phillip Sharp and Richard Roberts won the Nobel Prize for their discovery of split gene theory. Learn about the breakthrough with the help of an online interactive. Hear both scientists explain it in their own words, watch an...
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