Mystery of the Crooked Cell

This Mystery of the Crooked Cell lesson plan also includes:

Can your class solve the Mystery of the Crooked Cell? Junior geneticists collaborate to learn about sickle cell anemia in a fascinating lesson plan. The included materials help them to examine the genetic factors behind the disease through Punnett squares, the disease's effects on those who have it, and how to determine the presence of the sickle cell gene through gel electrophoresis.

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CCSS: Designed
NGSS: Designed
Instructional Ideas

  • Use the additional web-based resources to take a closer look at sickle cell anemia
  • Extend the lesson with one of many suggestions in the Teacher's Guide
Classroom Considerations

  • Teachers can borrow materials for the experiments through the Maryland Loaner Lab program; check for availability if you are outside of Maryland
  • Due to the technical nature of the lesson plan, some portions may require modification for younger learners
Pros

  • The plan provides a diverse set of individual and group activities
  • All printable materials, answer keys, and materials lists are located in the Teacher's Guide
  • The lab gives pupils experience in creating and working with gel electrophoresis plates, including interpretation of results
Cons

  • None